San Francisco 49ers
| Week # | Date | Opponent | Results | Record | Streak | |
|---|---|---|---|---|---|---|
| 10 | Sunday, Nov. 9 |
vs
LAR
|
L 42-26 | 6-4-0 | Lost 1 | Boxscore |
| 11 | Sunday, Nov. 16 |
@
Ari
|
W 41-22 | 7-4-0 | Won 1 | Boxscore |
| 12 | Monday, Nov. 24 |
vs
Car
|
W 20-9 | 8-4-0 | Won 2 | Boxscore |
| 13 | Sunday, Nov. 30 |
@
Cle
|
W 26-8 | 9-4-0 | Won 3 | Boxscore |
| 15 | Sunday, Dec. 14 |
vs
Ten
|
W 37-24 | 10-4-0 | Won 4 | Boxscore |
| 16 | Monday, Dec. 22 |
@
Ind
|
W 48-27 | 11-4-0 | Won 5 | Boxscore |
| 17 | Sunday, Dec. 28 |
vs
Chi
|
W 42-38 | 12-4-0 | Won 6 | Boxscore |
| 18 | Saturday, Jan. 3 |
vs
Sea
|
L 13-3 | 12-5-0 | Lost 1 | Boxscore |
| 19 | Sunday, Jan. 11 |
@
Phi
|
W 23-19 | Boxscore | ||
| 20 | Saturday, Jan. 17 |
@
Sea
|
L 41-6 | Boxscore |
VS.
San Francisco 49ers
STAT
RANK
244.53
268.06
Passing yards per game
Los Angeles Rams
5
1
106.88
159.65
Rushing yards per game
Buffalo Bills
24
1
25.71
30.47
Points for per game
Los Angeles Rams
10
1
21.82
15.57
Points against per game
Buffalo Bills
77
1
15
30
Rushing touchdowns
Buffalo Bills
18
1
33
46
Passing touchdowns
Los Angeles Rams
4
1
50
67
Total touchdowns
Los Angeles Rams
10
1
20
68
Sacks
Denver Broncos
32
1
545
615
Tackles
Las Vegas Raiders
24
1
6
23
Interceptions
Chicago Bears
29
1
232.41
156.94
Opponent passing yards per game
Buffalo Bills
25
1
107.82
78.00
Opponent rushing yards per game
Tampa Bay Buccaneers
43
1
5-3-0
8-1-0
Home
Denver Broncos
12
1
7-2-0
8-0-0
Away
New England Patriots
3
1
4-2-0
5-1-0
Against division
Houston Texans
6
1
May 11, 2026
| Larry Worth III (S) | Signed as an undrafted free agent by the San Francisco 49ers. |
| Milo Eifler (LB) | Waived by the San Francisco 49ers. |
May 8, 2026
| Carver Willis (OG) | Signed by the San Francisco 49ers to a four-year contract. |
| De'Zhaun Stribling (WR) | Signed by the San Francisco 49ers to a four-year contract. |
| Enrique Cruz Jr. (OT) | Signed by the San Francisco 49ers to a four-year contract. |
| Ephesians Prysock (CB) | Signed by the San Francisco 49ers to a four-year contract. |
| Jaden Dugger (LB) | Signed by the San Francisco 49ers to a four-year contract. |
| Kaelon Black (RB) | Signed by the San Francisco 49ers to a four-year contract. |
| Wesley Grimes (WR) | Signed as an undrafted free agent by the San Francisco 49ers. |