San Francisco 49ers
| Week # | Date | Opponent | Results | Record | Streak | |
|---|---|---|---|---|---|---|
| 4 | Sunday, Sep. 28 |
vs
Jax
|
L 26-21 | 3-1-0 | Lost 1 | Boxscore |
| 5 | Thursday, Oct. 2 |
@
LAR
|
W 26-23 | 4-1-0 | Won 1 | Boxscore |
| 6 | Sunday, Oct. 12 |
@
TB
|
L 30-19 | 4-2-0 | Lost 1 | Boxscore |
| 7 | Sunday, Oct. 19 |
vs
Atl
|
W 20-10 | 5-2-0 | Won 1 | Boxscore |
| 8 | Sunday, Oct. 26 |
@
Hou
|
L 26-15 | 5-3-0 | Lost 1 | Boxscore |
| 9 | Sunday, Nov. 2 |
@
NYG
|
W 34-24 | 6-3-0 | Won 1 | Boxscore |
| 10 | Sunday, Nov. 9 |
vs
LAR
|
L 42-26 | 6-4-0 | Lost 1 | Boxscore |
| 11 | Sunday, Nov. 16 |
@
Ari
|
W 41-22 | 7-4-0 | Won 1 | Boxscore |
| 12 | Monday, Nov. 24 |
vs
Car
|
W 20-9 | 8-4-0 | Won 2 | Boxscore |
| 13 | Sunday, Nov. 30 |
@
Cle
|
W 26-8 | 9-4-0 | Won 3 | Boxscore |
VS.
San Francisco 49ers
STAT
RANK
242.62
275.46
Passing yards per game
Dallas Cowboys
6
1
98.54
157.77
Rushing yards per game
Buffalo Bills
25
1
23.62
30.31
Points for per game
Detroit Lions
16
1
20.69
15.57
Points against per game
Buffalo Bills
72
1
11
24
Rushing touchdowns
Indianapolis Colts
19
1
22
35
Passing touchdowns
Los Angeles Rams
9
1
33
50
Total touchdowns
Buffalo Bills
20
1
16
55
Sacks
Denver Broncos
32
1
426
501
Tackles
Atlanta Falcons
21
1
5
18
Interceptions
Chicago Bears
28
1
232.00
165.15
Opponent passing yards per game
Cleveland Browns
25
1
103.77
78.00
Opponent rushing yards per game
Tampa Bay Buccaneers
44
1
3-2-0
6-0-0
Home
Denver Broncos
17
1
6-2-0
6-0-0
Away
New England Patriots
3
1
4-1-0
4-0-0
Against division
Los Angeles Chargers
4
1
December 13, 2025
| Brandon Aiyuk (WR) | Placed on the reserve/left squad list by the San Francisco 49ers. |
| Jalen Graham (LB) | Activated from the practice squad by the San Francisco 49ers. |
| Sebastian Valdez (DT) | Activated from the practice squad by the San Francisco 49ers. |
December 11, 2025
| Yetur Gross-Matos (DE/LB) | Placed on the designated for return list by the San Francisco 49ers. |
December 10, 2025
| Isaiah Bolden (CB) | Signed by the San Francisco 49ers to the practice squad. |
December 9, 2025
| Adrian Martinez (QB) | Released by the San Francisco 49ers from the practice squad. |
| Javon Baker (WR) | Signed by the San Francisco 49ers to the practice squad. |
| Matt Gay (PK) | Released by the San Francisco 49ers from the practice squad. |
December 8, 2025
| Garret Wallow (LB) | Claimed off waivers from the Denver Broncos. |
| Kurtis Rourke (QB) | Placed on the designated for return list by the San Francisco 49ers. |