San Francisco 49ers
| Week # | Date | Opponent | Results | Record | Streak | |
|---|---|---|---|---|---|---|
| 2 | Sunday, Sep. 14 |
@
NO
|
W 26-21 | 2-0-0 | Won 2 | Boxscore |
| 3 | Sunday, Sep. 21 |
vs
Ari
|
W 16-15 | 3-0-0 | Won 3 | Boxscore |
| 4 | Sunday, Sep. 28 |
vs
Jax
|
L 26-21 | 3-1-0 | Lost 1 | Boxscore |
| 5 | Thursday, Oct. 2 |
@
LAR
|
W 26-23 | 4-1-0 | Won 1 | Boxscore |
| 6 | Sunday, Oct. 12 |
@
TB
|
L 30-19 | 4-2-0 | Lost 1 | Boxscore |
| 7 | Sunday, Oct. 19 |
vs
Atl
|
W 20-10 | 5-2-0 | Won 1 | Boxscore |
| 8 | Sunday, Oct. 26 |
@
Hou
|
L 26-15 | 5-3-0 | Lost 1 | Boxscore |
| 9 | Sunday, Nov. 2 |
@
NYG
|
W 34-24 | 6-3-0 | Won 1 | Boxscore |
| 10 | Sunday, Nov. 9 |
vs
LAR
|
L 42-26 | 6-4-0 | Lost 1 | Boxscore |
| 11 | Sunday, Nov. 16 |
@
Ari
|
W 41-22 | 7-4-0 | Won 1 | Boxscore |
VS.
San Francisco 49ers
STAT
RANK
254.55
266.82
Passing yards per game
Dallas Cowboys
3
1
94.82
147.18
Rushing yards per game
Buffalo Bills
28
1
23.73
31.00
Points for per game
Indianapolis Colts
14
1
22.91
15.57
Points against per game
Buffalo Bills
80
1
8
22
Rushing touchdowns
Indianapolis Colts
19
1
20
30
Passing touchdowns
Los Angeles Rams
7
1
28
41
Total touchdowns
Indianapolis Colts
20
1
12
49
Sacks
Denver Broncos
32
1
366
423
Tackles
New York Giants
20
1
3
16
Interceptions
Chicago Bears
29
1
249.09
168.18
Opponent passing yards per game
Buffalo Bills
28
1
103.82
78.00
Opponent rushing yards per game
Tampa Bay Buccaneers
46
1
2-2-0
6-0-0
Home
Denver Broncos
18
1
5-2-0
6-0-0
Away
New England Patriots
4
1
4-1-0
2-0-0
Against division
Green Bay Packers
7
1
November 19, 2025
| Matt Gay (PK) | Signed by the San Francisco 49ers to the practice squad. |
| Russell Gage (WR) | Released by the San Francisco 49ers from the practice squad. |
| Stone Blanton (LB) | Re-signed by the San Francisco 49ers to the practice squad. |
November 18, 2025
| Adrian Martinez (QB) | Re-signed by the San Francisco 49ers to the practice squad. |
| Sincere McCormick (RB) | Released by the San Francisco 49ers from the practice squad. |