San Francisco 49ers
| Week # | Date | Opponent | Results | Record | Streak | |
|---|---|---|---|---|---|---|
| 1 | Sunday, Sep. 7 |
@
Sea
|
W 17-13 | 1-0-0 | Won 1 | Boxscore |
| 2 | Sunday, Sep. 14 |
@
NO
|
W 26-21 | 2-0-0 | Won 2 | Boxscore |
| 3 | Sunday, Sep. 21 |
vs
Ari
|
W 16-15 | 3-0-0 | Won 3 | Boxscore |
| 4 | Sunday, Sep. 28 |
vs
Jax
|
L 26-21 | 3-1-0 | Lost 1 | Boxscore |
| 5 | Thursday, Oct. 2 |
@
LAR
|
W 26-23 | 4-1-0 | Won 1 | Boxscore |
| 6 | Sunday, Oct. 12 |
@
TB
|
L 30-19 | 4-2-0 | Lost 1 | Boxscore |
| 7 | Sunday, Oct. 19 |
vs
Atl
|
W 20-10 | 5-2-0 | Won 1 | Boxscore |
| 8 | Sunday, Oct. 26 |
@
Hou
|
L 26-15 | 5-3-0 | Lost 1 | Boxscore |
| 9 | Sunday, Nov. 2 |
@
NYG
|
W 34-24 | 6-3-0 | Won 1 | Boxscore |
VS.
San Francisco 49ers
STAT RANK
November 1, 2025
| Clelin Ferrell (LB/DE) | Activated from the practice squad by the San Francisco 49ers. |
| Nick Zakelj (OG/C) | Activated from the practice squad by the San Francisco 49ers. |
| Spencer Burford (OT/OG) | Activated from injured reserve. |
| Yetur Gross-Matos (DE/LB) | Various injuries, injured reserve. |
October 30, 2025
| Andre Dillard (OT/OG) | Released by the San Francisco 49ers from the practice squad. |
| Brandon Parker (OT) | Re-signed by the San Francisco 49ers to the practice squad. |
October 29, 2025
| Clelin Ferrell (LB/DE) | Signed by the San Francisco 49ers to the practice squad. |
| Drew Moss (OG/C) | Waived by the San Francisco 49ers. |
| Keion White (DE/LB) | Acquired from the New England Patriots |
October 28, 2025
| Andre Dillard (OT/OG) | Re-signed by the San Francisco 49ers to the practice squad. |
| Brandon Parker (OT) | Released by the San Francisco 49ers from the practice squad. |