Indianapolis Colts
| Week # | Date | Opponent | Results | Record | Streak | |
|---|---|---|---|---|---|---|
| 1 | Sunday, Sep. 7 |
vs
Mia
|
W 33-8 | 1-0-0 | Won 1 | Boxscore |
| 2 | Sunday, Sep. 14 |
vs
Den
|
W 29-28 | 2-0-0 | Won 2 | Boxscore |
| 3 | Sunday, Sep. 21 |
@
Ten
|
W 41-20 | 3-0-0 | Won 3 | Boxscore |
| 4 | Sunday, Sep. 28 |
@
LAR
|
L 27-20 | 3-1-0 | Lost 1 | Boxscore |
| 5 | Sunday, Oct. 5 |
vs
LV
|
W 40-6 | 4-1-0 | Won 1 | Boxscore |
| 6 | Sunday, Oct. 12 |
vs
Ari
|
W 31-27 | 5-1-0 | Won 2 | Boxscore |
| 7 | Sunday, Oct. 19 |
@
LAC
|
W 38-24 | 6-1-0 | Won 3 | Boxscore |
| 8 | Sunday, Oct. 26 |
vs
Ten
|
W 38-14 | 7-1-0 | Won 4 | Boxscore |
| 9 | Sunday, Nov. 2 |
@
Pit
|
L 27-20 | 7-2-0 | Lost 1 | Boxscore |
| 10 | Sunday, Nov. 9 |
vs
Atl
|
W 31-25 | 8-2-0 | Won 1 | Boxscore |
VS.
Indianapolis Colts
STAT
RANK
251.60
258.70
Passing yards per game
Dallas Cowboys
3
1
145.30
147.18
Rushing yards per game
Buffalo Bills
3
1
32.10
32.10
Points for per game
Indianapolis Colts
1
1
20.60
15.57
Points against per game
Buffalo Bills
73
1
22
22
Rushing touchdowns
Indianapolis Colts
1
1
15
27
Passing touchdowns
Los Angeles Rams
20
1
39
40
Total touchdowns
Buffalo Bills
2
1
29
49
Sacks
Denver Broncos
8
1
343
394
Tackles
Miami Dolphins
25
1
10
15
Interceptions
Chicago Bears
4
1
235.30
167.00
Opponent passing yards per game
Cleveland Browns
25
1
92.30
78.00
Opponent rushing yards per game
Tampa Bay Buccaneers
37
1
6-0-0
6-0-0
Home
Denver Broncos
1
1
2-2-0
5-0-0
Away
New England Patriots
13
1
2-0-0
1-0-0
Against division
Green Bay Packers
1
1
November 22, 2025
| Cameron Mitchell (CB) | Waived by the Indianapolis Colts. |
| Charvarius Ward (CB) | Activated from injured reserve. |
November 18, 2025
| Chris Wormley (DE/DT) | Signed by the Indianapolis Colts to the practice squad. |
| Eli Pancol (WR) | Signed by the Indianapolis Colts to the practice squad. |
| George Odum (S) | Signed by the Indianapolis Colts to the practice squad. |
| Maximilian Mang (TE) | Released by the Indianapolis Colts from the practice squad. |
| Tanoh Kpassagnon (DE/LB) | Released by the Indianapolis Colts from the practice squad. |
| Troy Pride (CB) | Released by the Indianapolis Colts from the practice squad. |
| Viliami Fehoko Jr. (DE/DT) | Signed by the Indianapolis Colts to the practice squad. |