12:11 PM - Brandon Aiyuk (SF) 49ers remain committed to getting Aiyuk (knee) "healthy and back on the field" in 2025, even though the team had approximately $27 million in guarantees for the 2026 season voided in his contract, Mike Garafolo of NFL Network reports.

5:11 PM - Tatum Bethune (SF) (ankle) has been ruled out for Monday's game against Carolina, Cam Inman of The San Jose Mercury News reports.

5:09 PM - Eddy Pineiro (SF) (hamstring) has been ruled out for Monday's game against the Panthers, Cam Inman of The San Jose Mercury News reports.

7:07 PM - Brandon Aiyuk (SF) (knee) is considered unlikely to play for the 49ers again after the team voided guaranteed money in his contract for 2026, Diana Russini and Michael Silver of The Athletic reports.

6:24 PM - Matt Gay (SF) 49ers signed Gay to the practice squad Wednesday.

5:54 PM - Matt Gay (SF) is signing with the 49ers, Tom Pelissero of NFL Network reports.

5:18 PM - Tatum Bethune (SF) suffered a high-ankle sprain in Sunday's win over the Cardinals and is expected to miss multiple weeks, David Lombardi of SFStandard.com reports.

5:12 PM - Jacob Cowing (SF) Kyle Shanahan said Monday that Cowing's (hamstring) 21-day practice window will likely be opened following the 49ers' Week 14 bye, Matt Maiocco of NBC Sports Bay Area reports.

3:26 PM - Eddy Pineiro (SF) Kyle Shanahan said Monday that Pineiro (hamstring) is considered week-to-week, David Lombardi of SFStandard.com reports.

3:22 PM - Brandon Aiyuk (SF) Kyle Shanahan said Monday that Aiyuk's (knee) 21-day practice window will not be opened this week, and he remains week-to-week, Matt Barrows of The Athletic reports.

2:29 PM - Luke Farrell (SF) was not target as a receiver in Sunday's 41-22 victory over Arizona.

2:16 PM - Skyy Moore (SF) was not targeted as a receiver while returning two kicks for 107 combined yards in Sunday's 41-22 win over Arizona.

2:06 PM - Brian Robinson (SF) rushed eight times for 24 yards while failing to bring in his only target in Sunday's 41-22 win over Arizona.

1:57 PM - Demarcus Robinson (SF) had one reception on two targets for 13 yards in Sunday's 41-22 victory over the Cardinals.

1:45 PM - Kendrick Bourne (SF) was not targeted as a receiver in Sunday's 41-22 win over the Cardinals.

6:39 PM - Eddy Pineiro (SF) (hamstring) is questionable to return to Sunday's game against the Cardinals, Eric Branch of the San Francisco Chronicle reports.

5:25 PM - Robert Beal Jr. (SF) suffered a concussion in the first half of Sunday's contest against Arizona, Jennifer Lee Chan of NBC Sports Bay Area reports.

5:21 PM - Tatum Bethune (SF) (ankle) is questionable to return to Sunday's contest against the Cardinals, Jennifer Lee Chan of NBC Sports Bay Area reports.

3:06 PM - Jordan Watkins (SF) (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.

2:52 PM - Jordan James (SF) (coach's decision) is inactive for Sunday's game against the Cardinals, Briana Jeannel of the 49ers' official site reports.

2:46 PM - Deommodore Lenoir (SF) (calf) is active for Sunday's Week 11 matchup against Arizona, Eric Branch of the San Francisco Chronicle reports.

12:45 PM - Brock Purdy (SF) (toe) will be playing with no restrictions on Sunday, including no extra padding or a special shoe, Jay Glazer reported on Fox NFL Sunday.

6:59 PM - Mac Jones (SF) will return to a backup role with teammate Brock Purdy (toe) cleared to start Sunday's game against the Cardinals.

5:01 PM - Ricky Pearsall (SF) (knee) doesn't have an injury designation for Sunday's game against the Cardinals, Matt Barrows of The Athletic reports.

6:14 PM - Brock Purdy (SF) Kyle Shanahan said on the 49ers Game Plan on Thursday that Purdy (toe) is slated to start Sunday's game at Arizona, Matt Maiocco of NBC Sports Bay Area reports.

4:19 PM - Ricky Pearsall (SF) (knee) is returning to practice Wednesday, David Lombardi of SFStandard.com reports.

4:08 PM - Brock Purdy (SF) Kyle Shanahan said Purdy (toe) will be a limited but "aggressive" participant at Wednesday's practice with the intention to start Sunday's game at Arizona, Cam Inman of The San Jose Mercury News reports.

5:57 PM - Brandon Aiyuk (SF) Kyle Shanahan said Monday that the 49ers don't intend to open Aiyuk's (knee) practice window this week, Nick Wagoner of ESPN.com reports.

5:53 PM - Ricky Pearsall (SF) Kyle Shanahan said Monday that Pearsall (knee) has a chance to practice Wednesday, Matt Barrows of The Athletic reports.

5:47 PM - Brock Purdy (SF) Kyle Shanahan said Monday that Purdy (toe) will continue to increase his activity level this week, Nick Wagoner of ESPN.com reports.

3:17 PM - Luke Farrell (SF) had two receptions on as many targets for 15 yards and a touchdown in Sunday's 42-26 loss to the Rams.

2:49 PM - Jordan Watkins (SF) was limited to three snaps on offense (five percent) and did not garner a target in Sunday's 42-26 loss to the Rams.

2:41 PM - Skyy Moore (SF) secured his only target for 18 yards in Sunday's 42-26 loss to the Rams.

2:31 PM - Demarcus Robinson (SF) had three receptions on four targets for 34 yards in Sunday's 42-26 loss to the Rams.

2:22 PM - Kendrick Bourne (SF) caught his only target for 19 yards in Sunday's 42-26 loss to the Rams.

3:24 PM - Keion White (SF) (groin) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.

3:20 PM - Alfred Collins (SF) (hip) is inactive for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.

3:19 PM - Ben Bartch (SF) (ankle) is active for Sunday's battle against the Rams, Briana Jeannel of the 49ers' official site reports.

3:18 PM - Kalia Davis (SF) (ankle) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.

3:16 PM - Dee Winters (SF) (knee) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.

3:14 PM - Tatum Bethune (SF) (thigh) is active for Sunday's game against the Rams, Briana Jeannel of the 49ers' official site reports.

3:02 PM - Brock Purdy (SF) (toe) is listed as inactive Sunday versus the Rams, Briana Jeannel of the 49ers' official site reports.

5:03 PM - Ricky Pearsall (SF) (knee) has been ruled out for Sunday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.

5:01 PM - Mac Jones (SF) will start Sunday's game against the Rams even if Brock Purdy (toe) is active, Nick Wagoner of ESPN.com reports.

4:59 PM - Brock Purdy (SF) (toe) is listed as questionable for Sunday's game against the Rams, but Mac Jones will start even if is active, Nick Wagoner of ESPN.com reports.

6:51 PM - Ricky Pearsall (SF) (knee) didn't practice Thursday, Cam Inman of The San Jose Mercury News reports.

6:46 PM - Brock Purdy (SF) (toe) remained limited at Thursday's practice, Cam Inman of The San Jose Mercury News reports.

4:36 PM - Ricky Pearsall (SF) (knee) isn't practicing Wednesday, Matt Barrows of The Athletic reports.

4:19 PM - Brandon Aiyuk (SF) Francisco head coach Kyle Shanahan said Wednesday that he's "pretty confident" Aiyuk (knee) will play at some point this season, David Lombardi of SFStandard.com reports.

4:11 PM - Brock Purdy (SF) Kyle Shanahan said Purdy (toe) will be limited at Wednesday's practice, Matt Barrows of The Athletic reports.

5:14 PM - Ricky Pearsall (SF) Kyle Shanahan noted Monday that Pearsall (knee) has a chance to play Sunday against the Rams, but will be evaluated mid-week, Matt Barrows of The Athletic reports.

5:01 PM - Brandon Aiyuk (SF) Francisco head coach Kyle Shanahan said that Aiyuk (knee) won't have his 21-day practice window opened this week, David Lombardi of SFStandard.com reports.

2:19 PM - Jordan Watkins (SF) hauled in his only target for 19 yards in Sunday's 34-24 win over the Giants.

2:07 PM - Skyy Moore (SF) had one reception for 21 yards while returning five combined kicks for 85 yards in Sunday's 34-24 win over the Giants.

1:55 PM - Demarcus Robinson (SF) finished with no receptions on one target in Sunday's 34-24 win over the Giants.

1:31 PM - Brian Robinson (SF) took five carries for 53 yards and a touchdown in Sunday's 34-24 win over the Giants. He also returned a kickoff for 41 yards.

6:43 PM - Kendrick Bourne (SF) caught both of his targets for 34 yards in Sunday's 34-24 win over the Giants.

6:32 PM - Jauan Jennings (SF) caught four of five targets for 41 yards and a touchdown in Sunday's 34-24 win over the Giants.

6:30 PM - George Kittle (SF) caught all four of his targets for 32 yards in Sunday's 34-24 win over the Giants.

4:42 PM - Mac Jones (SF) completed 19 of 24 passes for 235 yards and two touchdowns in Sunday's 34-24 win over the Giants. He added four rushing attempts for four yards.

4:39 PM - Christian McCaffrey (SF) rushed 28 times for 106 yards and a touchdown while catching five of six targets for 67 yards and a touchdown in Sunday's 34-24 win over the Giants.

4:28 PM - Mykel Williams (SF) coach Kyle Shanahan said Mykel Williams might have injured his ACL in Sunday's win over the Giants, Vic Tafur of The Athletic reports.

12:43 PM - Jordan Elliott (SF) (ankle) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.

12:34 PM - Spencer Burford (SF) (knee) is active for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.

12:12 PM - Marques Sigle (SF) (coach's decision) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.

12:05 PM - Sam Okuayinonu (SF) (ankle) is active for Sunday's matchup with the Giants, Briana Jeannel of the 49ers' official site reports.

11:59 AM - Dee Winters (SF) (knee) is active for Sunday's contest against the Giants, Briana Jeannel of the 49ers' official site reports.

11:40 AM - Brock Purdy (SF) (toe) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.

7:32 PM - Upton Stout (SF) (shoulder) has no injury designation ahead of Sunday's game against the Giants.

6:34 PM - Yetur Gross-Matos (SF) (knee/hamstring) has been ruled out for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports.

6:24 PM - Bryce Huff (SF) (hamstring) has been ruled out for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports.

6:17 PM - Jordan Elliott (SF) (ankle) is questionable for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports.

6:13 PM - Dee Winters (SF) (knee) is listed as questionable for Sunday's game against the Giants, Jennifer Lee Chan of NBC Sports Bay Area reports.

4:34 PM - Ricky Pearsall (SF) (knee) won't play Sunday against the Giants, Cam Inman of The San Jose Mercury News reports.

4:31 PM - Mac Jones (SF) will start Sunday's game at the Giants, Matt Maiocco of NBC Sports Bay Area reports.

4:29 PM - Brock Purdy (SF) (toe) won't start Sunday's game against the Giants but is listed as questionable to be available in a backup capacity, Matt Maiocco of NBC Sports Bay Area reports.

8:04 PM - Dee Winters (SF) (knee) was a limited participant in Thursday's practice, Eric Branch of the San Francisco Chronicle reports.

6:13 PM - Brock Purdy (SF) (toe) was limited at Thursday's practice, Nick Wagoner of ESPN.com reports.

5:00 PM - Ricky Pearsall (SF) (knee) didn't take part in Thursday's practice, Cam Inman of The San Jose Mercury News reports.

7:09 PM - Mac Jones (SF) (knee/knee) practiced in full Wednesday, Eric Branch of the San Francisco Chronicle reports.

7:03 PM - Brock Purdy (SF) (toe) officially was limited at Wednesday's practice, Eric Branch of the San Francisco Chronicle reports.

4:31 PM - Ricky Pearsall (SF) (knee) isn't practicing Wednesday, Vic Tafur of The Athletic reports.

4:12 PM - Brock Purdy (SF) Kyle Shanahan said Purdy (toe) is expected to be limited at Wednesday's practice, Nick Wagoner of ESPN.com reports.

12:02 PM - Jake Tonges (SF) recorded a two-yard touchdown reception on his lone target while playing five of the 49ers' 48 snaps on offense in Sunday's 26-15 loss to the Texans.

11:55 AM - Jordan Watkins (SF) recorded a seven-yard reception on two targets in Sunday's 26-15 loss to the Texans.

11:50 AM - Isaac Guerendo (SF) played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans.

7:16 PM - Dee Winters (SF) coach Kyle Shanahan said Monday that Winters is considered day-to-day due to a knee injury he sustained during Sunday's 26-15 loss to the Texans, Jennifer Lee Chan of NBC Sports Bay Area reports.

6:42 PM - Brandon Aiyuk (SF) Kyle Shanahan said Monday that the 49ers don't intend to designate Aiyuk (knee) to return from the reserve/PUP list Wednesday, Matt Barrows of The Athletic reports.

6:35 PM - Mac Jones (SF) Kyle Shanahan said Monday that Jones suffered a bruised knee during Sunday's 26-15 loss at Houston and is "day-to-day," David Lombardi of SFStandard.com reports.

6:28 PM - Brock Purdy (SF) (toe) has a chance to return to action Sunday at the Giants, Nick Wagoner of ESPN.com reports. "It's too early to say," coach Kyle Shanahan said Monday. "I don't think it's a long shot. We'll see how he's doing on Wednesday."

1:35 PM - Skyy Moore (SF) failed to collect his only target on offense while returning two kicks for 52 yards in Sunday's 26-15 loss to the Texans.

1:25 PM - Demarcus Robinson (SF) pulled in two of three targets for five yards while catching a successful two-point attempt in Sunday's 26-15 loss to Houston.

1:19 PM - Brian Robinson (SF) did not record a touch on offense while returning three kicks for 99 yards in Sunday's 26-15 loss to the Texans.

6:46 PM - Eddy Pineiro (SF) made his lone extra-point try during the 49ers' 26-15 loss to the Texans on Sunday.

5:13 PM - Christian McCaffrey (SF) rushed eight times for 25 yards and brought in three of six targets for 43 yards in the 49ers' 26-15 loss to the Texans on Sunday.

3:41 PM - Sam Okuayinonu (SF) is questionable to return to Sunday's matchup against Houston due to an ankle injury, Nick Wagoner of ESPN.com reports.

3:35 PM - Dee Winters (SF) (knee) has been ruled out for the rest of Sunday's game against the Texans.

3:32 PM - Jordan Elliott (SF) (ankle) has been ruled out for the rest of Sunday's game against the Texans, Matt Maiocco of NBC Sports Bay Area reports.

2:48 PM - Jordan Elliott (SF) (ankle) is questionable to return to Sunday's game against Houston,

11:54 AM - Luke Gifford (SF) is active for Sunday's game against the Texans.