Buffalo Bills
| Week # | Date | Opponent | Results | Record | Streak | |
|---|---|---|---|---|---|---|
| 2 | Sunday, Sep. 14 |
@
NYJ
|
W 30-10 | 2-0-0 | Won 2 | Boxscore |
| 3 | Thursday, Sep. 18 |
vs
Mia
|
W 31-21 | 3-0-0 | Won 3 | Boxscore |
| 4 | Sunday, Sep. 28 |
vs
NO
|
W 31-19 | 4-0-0 | Won 4 | Boxscore |
| 5 | Sunday, Oct. 5 |
vs
NE
|
L 23-20 | 4-1-0 | Lost 1 | Boxscore |
| 6 | Monday, Oct. 13 |
@
Atl
|
L 24-14 | 4-2-0 | Lost 2 | Boxscore |
| 8 | Sunday, Oct. 26 |
@
Car
|
W 40-9 | 5-2-0 | Won 1 | Boxscore |
| 9 | Sunday, Nov. 2 |
vs
KC
|
W 28-21 | 6-2-0 | Won 2 | Boxscore |
| 10 | Sunday, Nov. 9 |
@
Mia
|
L 30-13 | 6-3-0 | Lost 1 | Boxscore |
| 11 | Sunday, Nov. 16 |
vs
TB
|
W 44-32 | 7-3-0 | Won 1 | Boxscore |
| 12 | Thursday, Nov. 20 |
@
Hou
|
L 23-19 | 7-4-0 | Lost 1 | Boxscore |
VS.
Buffalo Bills
STAT
RANK
234.64
258.70
Passing yards per game
Dallas Cowboys
9
1
147.18
147.18
Rushing yards per game
Buffalo Bills
1
1
28.27
32.10
Points for per game
Indianapolis Colts
5
1
22.91
15.57
Points against per game
Buffalo Bills
78
1
20
22
Rushing touchdowns
Indianapolis Colts
2
1
19
27
Passing touchdowns
Los Angeles Rams
8
1
40
40
Total touchdowns
Buffalo Bills
1
1
26
49
Sacks
Denver Broncos
11
1
366
394
Tackles
Miami Dolphins
5
1
7
15
Interceptions
Chicago Bears
14
1
168.18
167.00
Opponent passing yards per game
Cleveland Browns
2
1
148.91
78.00
Opponent rushing yards per game
Tampa Bay Buccaneers
62
1
5-1-0
6-0-0
Home
Denver Broncos
3
1
2-3-0
5-0-0
Away
New England Patriots
18
1
2-2-0
1-0-0
Against division
Green Bay Packers
17
1
November 21, 2025
| Gabe Davis (WR) | Reverted back to the Buffalo Bills practice squad. |
| Keleki Latu (TE) | Reverted back to the Buffalo Bills practice squad. |
November 20, 2025
| Gabe Davis (WR) | Activated from the practice squad by the Buffalo Bills. |
| Keleki Latu (TE) | Activated from the practice squad by the Buffalo Bills. |
| Mecole Hardman (WR) | Calf injury, injured reserve. |
November 18, 2025
| Brandon Codrington (CB) | Re-signed by the Buffalo Bills to the practice squad. |
November 17, 2025
| Gabe Davis (WR) | Reverted back to the Buffalo Bills practice squad. |
| Keleki Latu (TE) | Reverted back to the Buffalo Bills practice squad. |