Buffalo Bills
| Week # | Date | Opponent | Results | Record | Streak | |
|---|---|---|---|---|---|---|
| 4 | Sunday, Sep. 28 |
vs
NO
|
W 31-19 | 4-0-0 | Won 4 | Boxscore |
| 5 | Sunday, Oct. 5 |
vs
NE
|
L 23-20 | 4-1-0 | Lost 1 | Boxscore |
| 6 | Monday, Oct. 13 |
@
Atl
|
L 24-14 | 4-2-0 | Lost 2 | Boxscore |
| 8 | Sunday, Oct. 26 |
@
Car
|
W 40-9 | 5-2-0 | Won 1 | Boxscore |
| 9 | Sunday, Nov. 2 |
vs
KC
|
W 28-21 | 6-2-0 | Won 2 | Boxscore |
| 10 | Sunday, Nov. 9 |
@
Mia
|
L 30-13 | 6-3-0 | Lost 1 | Boxscore |
| 11 | Sunday, Nov. 16 |
vs
TB
|
W 44-32 | 7-3-0 | Won 1 | Boxscore |
| 12 | Thursday, Nov. 20 |
@
Hou
|
L 23-19 | 7-4-0 | Lost 1 | Boxscore |
| 13 | Sunday, Nov. 30 |
@
Pit
|
W 26-7 | 8-4-0 | Won 1 | Boxscore |
| 14 | Sunday, Dec. 7 |
vs
Cin
|
W 39-34 | 9-4-0 | Won 2 | Boxscore |
VS.
Buffalo Bills
STAT
RANK
225.92
275.46
Passing yards per game
Dallas Cowboys
11
1
157.77
157.77
Rushing yards per game
Buffalo Bills
1
1
28.92
30.31
Points for per game
Detroit Lions
5
1
22.54
15.57
Points against per game
Buffalo Bills
78
1
22
24
Rushing touchdowns
Indianapolis Colts
2
1
23
35
Passing touchdowns
Los Angeles Rams
5
1
50
50
Total touchdowns
Buffalo Bills
1
1
28
55
Sacks
Denver Broncos
20
1
409
501
Tackles
Atlanta Falcons
28
1
10
18
Interceptions
Chicago Bears
13
1
171.85
165.15
Opponent passing yards per game
Cleveland Browns
2
1
135.23
78.00
Opponent rushing yards per game
Tampa Bay Buccaneers
60
1
6-1-0
6-0-0
Home
Denver Broncos
2
1
3-3-0
6-0-0
Away
New England Patriots
14
1
2-2-0
4-0-0
Against division
Los Angeles Chargers
14
1
December 13, 2025
| Andre Jones Jr. (DE/LB) | Activated from the practice squad by the Buffalo Bills. |
| Dane Jackson (CB) | Activated from the practice squad by the Buffalo Bills. |
December 9, 2025
| M.J. Devonshire (CB) | Signed by the Buffalo Bills to the practice squad. |
| Nick Broeker (OG/OT) | Released by the Buffalo Bills from the practice squad. |
December 8, 2025
| Baylon Spector (LB) | Reverted back to the Buffalo Bills practice squad. |
| Morgan Fox (DE) | Reverted back to the Buffalo Bills practice squad. |