career regular season statistics    
  
  | Year | Team | League | 
          W           
            Wins           
         | 
        
          L           
            Losses           
         | 
        
          ERA           
            Earned Run Average           
         | 
        
          G           
            Games           
         | 
        
          GS           
            Games Started           
         | 
        
          CG           
            Complete Games           
         | 
        
          SHO           
            Shutouts           
         | 
        
          SV           
            Saves           
         | 
        
          HLD           
            Holds           
         | 
        
          IP           
            Innings Pitched           
         | 
        
          H           
            Hits Allowed           
         | 
        
          R           
            Runs Allowed           
         | 
        
          ER           
            Earned Runs           
         | 
        
          HR           
            Home Runs Allowed           
         | 
        
          BB           
            Walks           
         | 
        
          SO           
            Strikeouts           
         | 
        
          WHIP           
            Walks and Hits Per Inning Pitched           
         | 
      
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | San Francisco | NL | 11 | 8 | 3.65 | 32 | 32 | 1 | 0 | 0 | 0 | 182.1 | 148 | 81 | 74 | 22 | 73 | 186 | 1.21 | 
| 2024 | San Francisco | NL | 3 | 2 | 4.7 | 7 | 7 | 0 | 0 | 0 | 0 | 30.2 | 20 | 16 | 16 | 6 | 15 | 43 | 1.14 | 
| 2023 | Seattle | AL | 0 | 1 | 8.1 | 1 | 1 | 0 | 0 | 0 | 0 | 3.1 | 4 | 5 | 3 | 0 | 5 | 3 | 2.7 | 
| 2022 | Seattle | AL | 12 | 12 | 3.71 | 32 | 32 | 0 | 0 | 0 | 0 | 189 | 163 | 80 | 78 | 32 | 62 | 212 | 1.19 | 
| 2021 | Toronto | AL | 13 | 7 | 2.84 | 32 | 32 | 0 | 0 | 0 | 0 | 193.1 | 150 | 62 | 61 | 33 | 52 | 248 | 1.04 | 
| 2020 | Toronto | AL | 1 | 1 | 4.79 | 5 | 4 | 0 | 0 | 0 | 0 | 20.2 | 22 | 13 | 11 | 4 | 14 | 25 | 1.74 | 
| 2020 | Arizona | NL | 1 | 4 | 7.84 | 7 | 7 | 0 | 0 | 0 | 0 | 31 | 31 | 27 | 27 | 9 | 31 | 43 | 2 | 
| 2020 | Total Ari/Tor | MLB | 2 | 5 | 6.62 | 12 | 11 | 0 | 0 | 0 | 0 | 51.2 | 53 | 40 | 38 | 13 | 45 | 68 | 1.9 | 
| 2019 | Arizona | NL | 12 | 8 | 4.34 | 33 | 33 | 0 | 0 | 0 | 0 | 174.1 | 150 | 91 | 84 | 30 | 84 | 235 | 1.34 | 
| 2018 | Arizona | NL | 6 | 2 | 3.93 | 24 | 24 | 0 | 0 | 0 | 0 | 123.2 | 97 | 55 | 54 | 19 | 70 | 165 | 1.35 | 
| 2018 | Reno | AAA | 0 | 1 | 2.08 | 1 | 1 | 0 | 0 | 0 | 4.1 | 3 | 3 | 1 | 0 | 1 | 9 | 0.92 | |
| 2018 | Visalia | A | 0 | 0 | 7.71 | 1 | 1 | 0 | 0 | 0 | 2.1 | 5 | 5 | 2 | 2 | 0 | 3 | 2.15 | |
| 2017 | Arizona | NL | 15 | 5 | 2.89 | 28 | 28 | 1 | 1 | 0 | 0 | 162 | 116 | 57 | 52 | 23 | 71 | 218 | 1.15 | 
| 2017 | Visalia | A | 0 | 1 | 3.86 | 1 | 1 | 0 | 0 | 0 | 0 | 4.2 | 4 | 2 | 2 | 0 | 2 | 11 | 1.28 | 
| 2016 | Arizona | NL | 8 | 15 | 4.9 | 32 | 32 | 0 | 0 | 0 | 0 | 174.1 | 185 | 105 | 95 | 24 | 71 | 218 | 1.47 | 
| 2015 | Arizona | NL | 5 | 12 | 3.52 | 23 | 23 | 0 | 0 | 0 | 0 | 127.2 | 121 | 56 | 50 | 9 | 49 | 119 | 1.33 | 
| 2015 | Reno | AAA | 2 | 3 | 3.67 | 9 | 9 | 0 | 0 | 0 | 0 | 41.2 | 44 | 21 | 17 | 1 | 27 | 57 | 1.7 | 
| 2014 | Detroit | AL | 1 | 4 | 8.16 | 9 | 6 | 0 | 0 | 0 | 1 | 28.2 | 43 | 26 | 26 | 5 | 11 | 19 | 1.88 | 
| 2014 | Toledo | AAA | 7 | 6 | 4.22 | 20 | 19 | 0 | 0 | 0 | 100.1 | 106 | 51 | 47 | 6 | 44 | 75 | 1.5 | |
| 2013 | Harrisburg | AA | 5 | 2 | 3.72 | 11 | 11 | 1 | 1 | 0 | 58 | 56 | 28 | 24 | 4 | 21 | 60 | 1.33 | |
| 2013 | Potomac | A | 6 | 3 | 3.11 | 16 | 16 | 3 | 0 | 0 | 84 | 60 | 30 | 29 | 9 | 41 | 100 | 1.2 | |
| 2012 | Potomac | A | 4 | 12 | 6.56 | 22 | 21 | 0 | 0 | 0 | 105.2 | 122 | 85 | 77 | 14 | 49 | 86 | 1.62 | |
| 2011 | Hagerstown | A | 2 | 3 | 3.13 | 20 | 20 | 0 | 0 | 0 | 89 | 71 | 36 | 31 | 3 | 38 | 95 | 1.22 | |
| 2010 | Vermont | A | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | |
| Total | MLB | 88 | 81 | 3.94 | 265 | 261 | 2 | 1 | 0 | 1 | 1441 | 1250 | 674 | 631 | 216 | 608 | 1734 | 1.29 | |
| Total | AL | 27 | 25 | 3.7 | 79 | 75 | 0 | 0 | 0 | 1 | 435 | 382 | 186 | 179 | 74 | 144 | 507 | 1.21 | |
| Total | NL | 61 | 56 | 4.04 | 186 | 186 | 2 | 1 | 0 | 0 | 1006 | 868 | 488 | 452 | 142 | 464 | 1227 | 1.32 | |
| Total | AAA | 9 | 10 | 4 | 30 | 29 | 0 | 0 | 0 | 146.1 | 153 | 75 | 65 | 7 | 72 | 141 | 1.54 | ||
| Total | AA | 5 | 2 | 3.72 | 11 | 11 | 1 | 1 | 0 | 58 | 56 | 28 | 24 | 4 | 21 | 60 | 1.33 | ||
| Total | A | 12 | 19 | 4.43 | 61 | 59 | 3 | 0 | 0 | 286.2 | 262 | 158 | 141 | 28 | 130 | 297 | 1.37 |