career regular season statistics    
  
  | Year | Team | League | 
          W           
            Wins           
         | 
        
          L           
            Losses           
         | 
        
          ERA           
            Earned Run Average           
         | 
        
          G           
            Games           
         | 
        
          GS           
            Games Started           
         | 
        
          CG           
            Complete Games           
         | 
        
          SHO           
            Shutouts           
         | 
        
          SV           
            Saves           
         | 
        
          HLD           
            Holds           
         | 
        
          IP           
            Innings Pitched           
         | 
        
          H           
            Hits Allowed           
         | 
        
          R           
            Runs Allowed           
         | 
        
          ER           
            Earned Runs           
         | 
        
          HR           
            Home Runs Allowed           
         | 
        
          BB           
            Walks           
         | 
        
          SO           
            Strikeouts           
         | 
        
          WHIP           
            Walks and Hits Per Inning Pitched           
         | 
      
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | Chicago Cubs | NL | 11 | 7 | 3.68 | 23 | 23 | 0 | 0 | 0 | 0 | 129.2 | 110 | 54 | 53 | 24 | 27 | 98 | 1.06 | 
| 2024 | Chicago Cubs | NL | 12 | 8 | 3.27 | 28 | 28 | 0 | 0 | 0 | 0 | 165.1 | 154 | 67 | 60 | 21 | 33 | 125 | 1.13 | 
| 2023 | Chicago Cubs | NL | 8 | 10 | 4.84 | 30 | 29 | 0 | 0 | 1 | 0 | 154.1 | 156 | 96 | 83 | 27 | 41 | 140 | 1.28 | 
| 2022 | NY Yankees | AL | 14 | 5 | 3.91 | 32 | 32 | 0 | 0 | 0 | 0 | 177.1 | 168 | 78 | 77 | 26 | 32 | 151 | 1.13 | 
| 2021 | NY Yankees | AL | 8 | 6 | 4.3 | 29 | 29 | 0 | 0 | 0 | 0 | 144.1 | 130 | 73 | 69 | 24 | 44 | 140 | 1.21 | 
| 2021 | Scranton/WB | AAA | 0 | 0 | 6 | 1 | 1 | 0 | 0 | 0 | 3 | 4 | 2 | 2 | 0 | 0 | 2 | 1.33 | |
| 2020 | Pittsburgh-Injured | NL | - | - | |||||||||||||||
| 2019 | Pittsburgh | NL | 2 | 3 | 4.1 | 7 | 7 | 1 | 0 | 0 | 0 | 37.1 | 34 | 24 | 17 | 4 | 8 | 30 | 1.13 | 
| 2018 | Pittsburgh | NL | 14 | 10 | 3.2 | 32 | 32 | 2 | 1 | 0 | 0 | 191 | 179 | 69 | 68 | 20 | 46 | 179 | 1.18 | 
| 2017 | Pittsburgh | NL | 8 | 7 | 4.44 | 25 | 25 | 0 | 0 | 0 | 0 | 133.2 | 152 | 69 | 66 | 11 | 46 | 125 | 1.48 | 
| 2017 | Indianapolis | AAA | 0 | 1 | 4.09 | 2 | 2 | 0 | 0 | 0 | 0 | 11 | 12 | 6 | 5 | 0 | 2 | 15 | 1.27 | 
| 2017 | Altoona | AA | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 6 | 0.67 | 
| 2016 | Pittsburgh | NL | 5 | 4 | 3.38 | 18 | 18 | 0 | 0 | 0 | 0 | 104 | 99 | 40 | 39 | 13 | 17 | 85 | 1.12 | 
| 2016 | Indianapolis | AAA | 4 | 2 | 2.04 | 10 | 10 | 0 | 0 | 0 | 0 | 61.2 | 44 | 14 | 14 | 2 | 6 | 61 | 0.81 | 
| 2015 | DNP-Injured | - | - | - | |||||||||||||||
| 2014 | DNP-Injured | - | - | - | |||||||||||||||
| 2013 | Indianapolis | AAA | 1 | 3 | 3.89 | 6 | 6 | 0 | 0 | 0 | 37 | 31 | 16 | 16 | 1 | 16 | 37 | 1.27 | |
| 2013 | Altoona | AA | 4 | 7 | 3.67 | 20 | 19 | 0 | 0 | 0 | 110.1 | 112 | 54 | 45 | 8 | 36 | 106 | 1.34 | |
| 2012 | Altoona | AA | 3 | 0 | 1.59 | 3 | 3 | 0 | 0 | 0 | 17 | 11 | 3 | 3 | 0 | 1 | 18 | 0.71 | |
| 2012 | Bradenton | A | 6 | 8 | 3.82 | 23 | 23 | 2 | 0 | 0 | 125 | 109 | 57 | 53 | 10 | 37 | 98 | 1.17 | |
| 2011 | West Virginia | A | 2 | 3 | 3.98 | 23 | 23 | 0 | 0 | 0 | 92.2 | 89 | 45 | 41 | 9 | 22 | 97 | 1.2 | |
| Total | MLB | 82 | 60 | 3.87 | 224 | 223 | 3 | 1 | 1 | 0 | 1237 | 1182 | 570 | 532 | 170 | 294 | 1073 | 1.19 | |
| Total | NL | 60 | 49 | 3.8 | 163 | 162 | 3 | 1 | 1 | 0 | 915.1 | 884 | 419 | 386 | 120 | 218 | 782 | 1.2 | |
| Total | AL | 22 | 11 | 4.08 | 61 | 61 | 0 | 0 | 0 | 0 | 321.2 | 298 | 151 | 146 | 50 | 76 | 291 | 1.16 | |
| Total | AAA | 5 | 6 | 2.96 | 19 | 19 | 0 | 0 | 0 | 0 | 112.2 | 91 | 38 | 37 | 3 | 24 | 115 | 1.02 | |
| Total | AA | 7 | 7 | 3.31 | 24 | 23 | 0 | 0 | 0 | 0 | 130.1 | 124 | 57 | 48 | 8 | 38 | 130 | 1.24 | |
| Total | A | 8 | 11 | 3.89 | 46 | 46 | 2 | 0 | 0 | 217.2 | 198 | 102 | 94 | 19 | 59 | 195 | 1.18 |