career regular season statistics    
  
  | Year | Team | League | 
          W           
            Wins           
         | 
        
          L           
            Losses           
         | 
        
          ERA           
            Earned Run Average           
         | 
        
          G           
            Games           
         | 
        
          GS           
            Games Started           
         | 
        
          CG           
            Complete Games           
         | 
        
          SHO           
            Shutouts           
         | 
        
          SV           
            Saves           
         | 
        
          HLD           
            Holds           
         | 
        
          IP           
            Innings Pitched           
         | 
        
          H           
            Hits Allowed           
         | 
        
          R           
            Runs Allowed           
         | 
        
          ER           
            Earned Runs           
         | 
        
          HR           
            Home Runs Allowed           
         | 
        
          BB           
            Walks           
         | 
        
          SO           
            Strikeouts           
         | 
        
          WHIP           
            Walks and Hits Per Inning Pitched           
         | 
      
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | San Diego | NL | 5 | 5 | 5.37 | 15 | 15 | 0 | 0 | 0 | 0 | 72 | 66 | 44 | 43 | 14 | 19 | 68 | 1.18 | 
| 2024 | San Diego | NL | 7 | 3 | 3.31 | 16 | 16 | 0 | 0 | 0 | 0 | 81.2 | 65 | 32 | 30 | 12 | 22 | 78 | 1.07 | 
| 2023 | San Diego | NL | 8 | 10 | 4.56 | 24 | 24 | 0 | 0 | 0 | 0 | 136.1 | 134 | 71 | 69 | 18 | 43 | 141 | 1.3 | 
| 2022 | San Diego | NL | 16 | 8 | 3.1 | 30 | 30 | 0 | 0 | 0 | 0 | 194.2 | 148 | 67 | 67 | 22 | 37 | 197 | 0.95 | 
| 2021 | San Diego | NL | 8 | 11 | 4.22 | 30 | 30 | 0 | 0 | 0 | 0 | 166.1 | 138 | 81 | 78 | 28 | 44 | 199 | 1.09 | 
| 2020 | Chicago Cubs | NL | 8 | 3 | 2.01 | 12 | 12 | 0 | 0 | 0 | 0 | 76 | 59 | 18 | 17 | 5 | 14 | 93 | 0.96 | 
| 2019 | Chicago Cubs | NL | 6 | 8 | 3.98 | 31 | 31 | 0 | 0 | 0 | 0 | 178.2 | 140 | 82 | 79 | 33 | 56 | 229 | 1.1 | 
| 2018 | Chicago Cubs | NL | 1 | 3 | 4.95 | 8 | 8 | 0 | 0 | 0 | 0 | 40 | 36 | 24 | 22 | 7 | 21 | 49 | 1.43 | 
| 2018 | South Bend | A | 0 | 0 | 1.5 | 2 | 2 | 0 | 0 | 0 | 6 | 4 | 1 | 1 | 1 | 1 | 6 | 0.83 | |
| 2017 | LA Dodgers | NL | 4 | 3 | 3.44 | 9 | 9 | 0 | 0 | 0 | 0 | 49.2 | 44 | 20 | 19 | 7 | 13 | 61 | 1.15 | 
| 2017 | Texas | AL | 6 | 9 | 4.01 | 22 | 22 | 0 | 0 | 0 | 0 | 137 | 115 | 63 | 61 | 20 | 45 | 148 | 1.17 | 
| 2017 | Total Tex/LA | MLB | 10 | 12 | 3.88 | 31 | 31 | 0 | 0 | 0 | 0 | 186.2 | 159 | 83 | 80 | 27 | 58 | 209 | 11.62 | 
| 2016 | Texas | AL | 7 | 5 | 3.41 | 17 | 17 | 0 | 0 | 0 | 0 | 100.1 | 81 | 43 | 38 | 12 | 31 | 132 | 1.12 | 
| 2016 | Round Rock | AAA | 0 | 1 | 2.57 | 2 | 2 | 0 | 0 | 0 | 0 | 7 | 3 | 3 | 2 | 1 | 3 | 7 | 0.86 | 
| 2016 | Frisco | AA | 1 | 1 | 2.25 | 5 | 5 | 0 | 0 | 0 | 0 | 20 | 14 | 7 | 5 | 1 | 7 | 24 | 1.05 | 
| 2015 | Texas-Injury | AL | - | - | |||||||||||||||
| 2014 | Texas | AL | 10 | 7 | 3.06 | 22 | 22 | 2 | 1 | 0 | 0 | 144.1 | 133 | 54 | 49 | 13 | 49 | 182 | 1.26 | 
| 2013 | Texas | AL | 13 | 9 | 2.83 | 32 | 32 | 0 | 0 | 0 | 0 | 209.2 | 145 | 68 | 66 | 26 | 80 | 277 | 1.07 | 
| 2012 | Texas | AL | 16 | 9 | 3.9 | 29 | 29 | 0 | 0 | 0 | 0 | 191.1 | 156 | 89 | 83 | 14 | 89 | 221 | 1.28 | 
| 2011 | Nippon | Japan | 18 | 6 | 1.44 | 28 | 28 | 10 | 6 | 0 | 232 | 156 | 42 | 37 | 5 | 36 | 276 | 0.83 | |
| 2010 | Nippon | Japan | 12 | 8 | 1.78 | 25 | 25 | 10 | 2 | 0 | 202 | 158 | 48 | 40 | 5 | 47 | 222 | 1.01 | |
| 2009 | Nippon | Japan | 15 | 5 | 1.73 | 23 | 23 | 8 | 2 | 0 | 182 | 118 | 36 | 35 | 9 | 45 | 167 | 0.9 | |
| 2008 | Nippon | Japan | 16 | 4 | 1.88 | 25 | 25 | 10 | 2 | 0 | 200.2 | 136 | 44 | 42 | 11 | 44 | 208 | 0.9 | |
| 2007 | Nippon | Japan | 15 | 5 | 1.82 | 26 | 26 | 12 | 3 | 0 | 207.2 | 123 | 48 | 42 | 9 | 49 | 210 | 0.83 | |
| 2006 | Nippon | Japan | 12 | 5 | 2.89 | 25 | 24 | 3 | 2 | 0 | 149.2 | 128 | 55 | 48 | 12 | 64 | 115 | 1.28 | |
| 2005 | Nippon | Japan | 5 | 5 | 3.53 | 14 | 14 | 2 | 1 | 0 | 94.1 | 97 | 37 | 37 | 7 | 48 | 52 | 1.54 | |
| Total | MLB | 115 | 93 | 3.65 | 297 | 297 | 2 | 1 | 0 | 0 | 1778 | 1460 | 756 | 721 | 231 | 563 | 2075 | 1.14 | |
| Total | AL | 52 | 39 | 3.42 | 122 | 122 | 2 | 1 | 0 | 0 | 782.2 | 630 | 317 | 297 | 85 | 294 | 960 | 1.18 | |
| Total | NL | 63 | 54 | 3.83 | 175 | 175 | 0 | 0 | 0 | 0 | 995.1 | 830 | 439 | 424 | 146 | 269 | 1115 | 1.1 | |
| Total | AAA | 0 | 1 | 2.57 | 2 | 2 | 0 | 0 | 0 | 7 | 3 | 3 | 2 | 1 | 3 | 7 | 0.86 | ||
| Total | AA | 1 | 1 | 2.25 | 5 | 5 | 0 | 0 | 0 | 20 | 14 | 7 | 5 | 1 | 7 | 24 | 1.05 | ||
| Total | A | 0 | 0 | 1.5 | 2 | 2 | 0 | 0 | 0 | 6 | 4 | 1 | 1 | 1 | 1 | 6 | 0.83 | ||
| Total | Japan | 93 | 38 | 1.99 | 166 | 165 | 55 | 18 | 0 | 1268.1 | 916 | 310 | 281 | 58 | 333 | 1250 | 0.98 |