career regular season statistics    
  
  | Year | Team | League | 
          W           
            Wins           
         | 
        
          L           
            Losses           
         | 
        
          ERA           
            Earned Run Average           
         | 
        
          G           
            Games           
         | 
        
          GS           
            Games Started           
         | 
        
          CG           
            Complete Games           
         | 
        
          SHO           
            Shutouts           
         | 
        
          SV           
            Saves           
         | 
        
          HLD           
            Holds           
         | 
        
          IP           
            Innings Pitched           
         | 
        
          H           
            Hits Allowed           
         | 
        
          R           
            Runs Allowed           
         | 
        
          ER           
            Earned Runs           
         | 
        
          HR           
            Home Runs Allowed           
         | 
        
          BB           
            Walks           
         | 
        
          SO           
            Strikeouts           
         | 
        
          WHIP           
            Walks and Hits Per Inning Pitched           
         | 
      
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2023 | Texas | AL | 0 | 1 | 7.16 | 16 | 0 | 0 | 0 | 0 | 0 | 16.1 | 16 | 15 | 13 | 4 | 7 | 21 | 1.41 | 
| 2023 | Round Rock | AAA | 1 | 0 | 3.51 | 22 | 0 | 0 | 0 | 3 | 25.2 | 20 | 11 | 10 | 5 | 9 | 30 | 1.13 | |
| 2022 | Arizona | NL | 4 | 7 | 5.36 | 57 | 0 | 0 | 0 | 10 | 10 | 50.1 | 57 | 33 | 30 | 11 | 22 | 44 | 1.57 | 
| 2022 | ACL D-backs Blue | R | 0 | 0 | 27 | 1 | 1 | 0 | 0 | 0 | 1 | 5 | 3 | 3 | 0 | 0 | 2 | 5 | |
| 2021 | Philadelphia | NL | 3 | 1 | 4.13 | 23 | 0 | 0 | 0 | 10 | 0 | 24 | 18 | 12 | 11 | 7 | 10 | 27 | 1.17 | 
| 2021 | Texas | AL | 0 | 0 | 2.51 | 32 | 0 | 0 | 0 | 16 | 0 | 32.1 | 27 | 9 | 9 | 5 | 7 | 35 | 1.05 | 
| 2021 | Total Tex/Phi | MLB | 3 | 1 | 3.2 | 55 | 0 | 0 | 0 | 26 | 0 | 56.1 | 45 | 21 | 20 | 12 | 17 | 62 | 1.1 | 
| 2020 | Kansas City | AL | 0 | 2 | 9 | 15 | 1 | 0 | 0 | 0 | 2 | 14 | 20 | 17 | 14 | 7 | 5 | 15 | 1.79 | 
| 2019 | Kansas City | AL | 3 | 2 | 3.41 | 63 | 0 | 0 | 0 | 30 | 1 | 63.1 | 64 | 24 | 24 | 6 | 17 | 73 | 1.28 | 
| 2018 | Kansas City | AL | 3 | 9 | 4.66 | 22 | 22 | 0 | 0 | 0 | 0 | 119.2 | 125 | 66 | 62 | 20 | 40 | 105 | 1.38 | 
| 2018 | Omaha | AAA | 0 | 1 | 7.36 | 1 | 1 | 0 | 0 | 0 | 3.2 | 4 | 3 | 3 | 0 | 1 | 2 | 1.36 | |
| 2018 | Northwest Arkansas | AA | 0 | 1 | 13.5 | 1 | 1 | 0 | 0 | 0 | 4 | 7 | 6 | 6 | 0 | 2 | 5 | 2.25 | |
| 2017 | Kansas City | AL | 5 | 13 | 5.38 | 30 | 30 | 0 | 0 | 0 | 0 | 154 | 143 | 99 | 92 | 34 | 61 | 131 | 1.32 | 
| 2016 | Kansas City | AL | 11 | 11 | 3.68 | 33 | 33 | 0 | 0 | 0 | 0 | 195.2 | 173 | 81 | 80 | 33 | 66 | 184 | 1.22 | 
| 2015 | San Diego | NL | 9 | 15 | 4.28 | 30 | 30 | 0 | 0 | 0 | 0 | 168.1 | 166 | 95 | 80 | 31 | 52 | 174 | 1.3 | 
| 2014 | San Diego | NL | 13 | 13 | 3.63 | 33 | 33 | 0 | 0 | 0 | 0 | 201 | 189 | 85 | 81 | 16 | 70 | 207 | 1.29 | 
| 2013 | San Diego | NL | 4 | 2 | 4.24 | 10 | 10 | 0 | 0 | 0 | 0 | 57.1 | 52 | 29 | 27 | 9 | 25 | 55 | 1.34 | 
| 2013 | Arizona | NL | 3 | 8 | 5.23 | 21 | 21 | 0 | 0 | 0 | 0 | 124 | 128 | 79 | 72 | 18 | 48 | 108 | 1.42 | 
| 2013 | Total Ari/SD | NL | 7 | 10 | 4.91 | 31 | 31 | 0 | 0 | 0 | 0 | 181.1 | 180 | 108 | 99 | 27 | 73 | 163 | 1.4 | 
| 2012 | Arizona | NL | 15 | 12 | 4.02 | 33 | 33 | 1 | 0 | 0 | 0 | 208.1 | 216 | 101 | 93 | 28 | 55 | 187 | 1.3 | 
| 2011 | Arizona | NL | 21 | 4 | 2.88 | 33 | 33 | 1 | 1 | 0 | 0 | 222 | 186 | 73 | 71 | 19 | 55 | 198 | 1.09 | 
| 2010 | Arizona | NL | 9 | 10 | 3.8 | 32 | 32 | 0 | 0 | 0 | 0 | 194 | 163 | 87 | 82 | 26 | 70 | 168 | 1.2 | 
| 2009 | NY Yankees | AL | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 
| 2009 | Scranton/Wilkes-Barre | AAA | 1 | 0 | 1.59 | 4 | 4 | 0 | 0 | 0 | 22.2 | 18 | 5 | 4 | 0 | 7 | 25 | 1.1 | |
| 2008 | NY Yankees | AL | 0 | 4 | 8.17 | 10 | 9 | 0 | 0 | 0 | 0 | 39.2 | 50 | 37 | 36 | 5 | 26 | 27 | 1.92 | 
| 2008 | Scranton/Wilkes-Barre | AAA | 5 | 3 | 2.35 | 13 | 12 | 0 | 0 | 0 | 69 | 52 | 19 | 18 | 4 | 17 | 72 | 1 | |
| 2008 | Tampa | A | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 4 | 0.6 | |
| 2008 | GCL Yankees | R | 1 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 1 | 0 | 0 | 7 | 1 | |
| 2007 | NY Yankees | AL | 1 | 0 | 1.89 | 3 | 3 | 0 | 0 | 0 | 0 | 19 | 13 | 6 | 4 | 1 | 9 | 15 | 1.16 | 
| 2007 | Scranton/Wilkes-Barre | AAA | 1 | 1 | 2.08 | 6 | 6 | 0 | 0 | 0 | 34.2 | 25 | 8 | 8 | 2 | 11 | 34 | 1.04 | |
| 2007 | Trenton | AA | 5 | 1 | 2.59 | 9 | 9 | 0 | 0 | 0 | 48.2 | 27 | 14 | 14 | 2 | 17 | 57 | 0.9 | |
| 2007 | Tampa | A | 6 | 1 | 1.29 | 11 | 10 | 1 | 0 | 0 | 63 | 39 | 9 | 9 | 2 | 22 | 72 | 0.97 | |
| 2006 | Staten Island | A | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 2.2 | 2 | 0 | 0 | 0 | 2 | 2 | 1.5 | |
| 2006 | USC | NCAA | 5 | 7 | 3.9 | 16 | 15 | 1 | 0 | 0 | 101.2 | 100 | 57 | 44 | 4 | 36 | 102 | 1.34 | |
| 2005 | USC | NCAA | 12 | 3 | 2.54 | 18 | 17 | 1 | 1 | 0 | 117 | 85 | 40 | 33 | 38 | 158 | 1.05 | ||
| 2004 | USC | NCAA | 7 | 2 | 2.91 | 16 | 15 | 0 | 0 | 1 | 92.2 | 86 | 34 | 30 | 4 | 31 | 120 | 1.26 | |
| Total | MLB | 104 | 114 | 4.16 | 497 | 290 | 2 | 1 | 66 | 14 | 1904.1 | 1806 | 948 | 881 | 280 | 647 | 1775 | 1.29 | |
| Total | AL | 23 | 42 | 4.59 | 225 | 98 | 0 | 0 | 46 | 4 | 655 | 631 | 354 | 334 | 115 | 240 | 607 | 1.33 | |
| Total | NL | 81 | 72 | 3.94 | 272 | 192 | 2 | 1 | 20 | 10 | 1249.1 | 1175 | 594 | 547 | 165 | 407 | 1168 | 1.27 | |
| Total | AAA | 7 | 5 | 2.28 | 24 | 23 | 0 | 0 | 0 | 130 | 99 | 35 | 33 | 6 | 36 | 133 | 1.04 | ||
| Total | AA | 5 | 2 | 3.42 | 10 | 10 | 0 | 0 | 0 | 52.2 | 34 | 20 | 20 | 2 | 19 | 62 | 1.01 | ||
| Total | A | 6 | 1 | 1.15 | 13 | 12 | 1 | 0 | 0 | 70.2 | 43 | 9 | 9 | 2 | 25 | 78 | 0.96 | ||
| Total | R | 1 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 1 | 0 | 0 | 7 | 1 | ||
| Total | NCAA | 24 | 12 | 3.09 | 50 | 47 | 2 | 1 | 1 | 311.1 | 271 | 131 | 107 | 8 | 105 | 380 | 1.21 |